A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Autores principales: Srinivasan Chinnapaiyan (Autor), Maria-Jose Santiago (Autor), Kingshuk Panda (Autor), Md. Sohanur Rahman (Autor), Jessica Alluin (Autor), John Rossi (Autor), Hoshang J. Unwalla (Autor)
• Formato: Libro
• Publicado: Elsevier, 2023-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...