A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Egile Nagusiak: Srinivasan Chinnapaiyan (Egilea), Maria-Jose Santiago (Egilea), Kingshuk Panda (Egilea), Md. Sohanur Rahman (Egilea), Jessica Alluin (Egilea), John Rossi (Egilea), Hoshang J. Unwalla (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2023-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...