A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Auteurs principaux: Srinivasan Chinnapaiyan (Auteur), Maria-Jose Santiago (Auteur), Kingshuk Panda (Auteur), Md. Sohanur Rahman (Auteur), Jessica Alluin (Auteur), John Rossi (Auteur), Hoshang J. Unwalla (Auteur)
• Format: Livre
• Publié: Elsevier, 2023-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...