A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• मुख्य लेखकों: Srinivasan Chinnapaiyan (लेखक), Maria-Jose Santiago (लेखक), Kingshuk Panda (लेखक), Md. Sohanur Rahman (लेखक), Jessica Alluin (लेखक), John Rossi (लेखक), Hoshang J. Unwalla (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...