A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Autori principali: Srinivasan Chinnapaiyan (Autore), Maria-Jose Santiago (Autore), Kingshuk Panda (Autore), Md. Sohanur Rahman (Autore), Jessica Alluin (Autore), John Rossi (Autore), Hoshang J. Unwalla (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...