A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• 主要な著者: Srinivasan Chinnapaiyan (著者), Maria-Jose Santiago (著者), Kingshuk Panda (著者), Md. Sohanur Rahman (著者), Jessica Alluin (著者), John Rossi (著者), Hoshang J. Unwalla (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...