A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Үндсэн зохиолчид: Srinivasan Chinnapaiyan (Зохиогч), Maria-Jose Santiago (Зохиогч), Kingshuk Panda (Зохиогч), Md. Sohanur Rahman (Зохиогч), Jessica Alluin (Зохиогч), John Rossi (Зохиогч), Hoshang J. Unwalla (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2023-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...