A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Váldodahkkit: Srinivasan Chinnapaiyan (Dahkki), Maria-Jose Santiago (Dahkki), Kingshuk Panda (Dahkki), Md. Sohanur Rahman (Dahkki), Jessica Alluin (Dahkki), John Rossi (Dahkki), Hoshang J. Unwalla (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2023-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...