A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Asıl Yazarlar: Srinivasan Chinnapaiyan (Yazar), Maria-Jose Santiago (Yazar), Kingshuk Panda (Yazar), Md. Sohanur Rahman (Yazar), Jessica Alluin (Yazar), John Rossi (Yazar), Hoshang J. Unwalla (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...