A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Автори: Srinivasan Chinnapaiyan (Автор), Maria-Jose Santiago (Автор), Kingshuk Panda (Автор), Md. Sohanur Rahman (Автор), Jessica Alluin (Автор), John Rossi (Автор), Hoshang J. Unwalla (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...