Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits

• Main Authors: Seyedeh Nesa Rezaeian Shiadeh (Author), Farzin Hadizadeh (Author), Elham Khodaverdi (Author), Mahmoud Gorji Valokola (Author), Saleh Rakhshani (Author), Hossein Kamali (Author), Ali Nokhodchi (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current research, novel drug delivery systems based on in situ forming gel (ISFG) (PLGA-PEG-PLGA) and in situ forming implant (ISFI) (PLGA) were developed for one-month risperidone delivery. In vitro release evaluation, pharmacokinetics, and histopathology studies of ISFI, ISFG, and Risperdal...