Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits

• Päätekijät: Seyedeh Nesa Rezaeian Shiadeh (Tekijä), Farzin Hadizadeh (Tekijä), Elham Khodaverdi (Tekijä), Mahmoud Gorji Valokola (Tekijä), Saleh Rakhshani (Tekijä), Hossein Kamali (Tekijä), Ali Nokhodchi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2023-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

In the current research, novel drug delivery systems based on in situ forming gel (ISFG) (PLGA-PEG-PLGA) and in situ forming implant (ISFI) (PLGA) were developed for one-month risperidone delivery. In vitro release evaluation, pharmacokinetics, and histopathology studies of ISFI, ISFG, and Risperdal...