Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits

• Hoofdauteurs: Seyedeh Nesa Rezaeian Shiadeh (Auteur), Farzin Hadizadeh (Auteur), Elham Khodaverdi (Auteur), Mahmoud Gorji Valokola (Auteur), Saleh Rakhshani (Auteur), Hossein Kamali (Auteur), Ali Nokhodchi (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In the current research, novel drug delivery systems based on in situ forming gel (ISFG) (PLGA-PEG-PLGA) and in situ forming implant (ISFI) (PLGA) were developed for one-month risperidone delivery. In vitro release evaluation, pharmacokinetics, and histopathology studies of ISFI, ISFG, and Risperdal...