Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits

• Autori principali: Seyedeh Nesa Rezaeian Shiadeh (Autore), Farzin Hadizadeh (Autore), Elham Khodaverdi (Autore), Mahmoud Gorji Valokola (Autore), Saleh Rakhshani (Autore), Hossein Kamali (Autore), Ali Nokhodchi (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In the current research, novel drug delivery systems based on in situ forming gel (ISFG) (PLGA-PEG-PLGA) and in situ forming implant (ISFI) (PLGA) were developed for one-month risperidone delivery. In vitro release evaluation, pharmacokinetics, and histopathology studies of ISFI, ISFG, and Risperdal...