HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

• 主要な著者: Lishomwa C Ndhlovu (著者), Fabio E Leal (著者), Aaron M Hasenkrug (著者), Aashish R Jha (著者), Karina I Carvalho (著者), Ijeoma G Eccles-James (著者), Fernanda R Bruno (著者), Raphaella G S Vieira (著者), Vanessa A York (著者), Glen M Chew (著者), R Brad Jones (著者), Yuetsu Tanaka (著者), Walter K Neto (著者), Sabri S Sanabani (著者), Mario A Ostrowski (著者), Aluisio C Segurado (著者), Douglas F Nixon (著者), Esper G Kallas (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2011-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurologic...