HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

• Главные авторы: Lishomwa C Ndhlovu (Автор), Fabio E Leal (Автор), Aaron M Hasenkrug (Автор), Aashish R Jha (Автор), Karina I Carvalho (Автор), Ijeoma G Eccles-James (Автор), Fernanda R Bruno (Автор), Raphaella G S Vieira (Автор), Vanessa A York (Автор), Glen M Chew (Автор), R Brad Jones (Автор), Yuetsu Tanaka (Автор), Walter K Neto (Автор), Sabri S Sanabani (Автор), Mario A Ostrowski (Автор), Aluisio C Segurado (Автор), Douglas F Nixon (Автор), Esper G Kallas (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2011-04-01T00:00:00Z.
• Предметы: article
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The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurologic...