HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

• Main Authors: Lishomwa C Ndhlovu (Author), Fabio E Leal (Author), Aaron M Hasenkrug (Author), Aashish R Jha (Author), Karina I Carvalho (Author), Ijeoma G Eccles-James (Author), Fernanda R Bruno (Author), Raphaella G S Vieira (Author), Vanessa A York (Author), Glen M Chew (Author), R Brad Jones (Author), Yuetsu Tanaka (Author), Walter K Neto (Author), Sabri S Sanabani (Author), Mario A Ostrowski (Author), Aluisio C Segurado (Author), Douglas F Nixon (Author), Esper G Kallas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurologic...