Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

• Main Authors: Xian-Qin Luo (Author), Ao Li (Author), Xue Yang (Author), Xiao Xiao (Author), Rong Hu (Author), Tian-Wen Wang (Author), Xiao-Yun Dou (Author), Da-Jian Yang (Author), Zhi Dong (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages in the brain may accelerate the progression of VD. Endocannabinoids are...