Associations between one-carbon metabolism and valproic acid-induced liver dysfunction in epileptic patients

• Váldodahkkit: Jingwei Zhu (Dahkki), Zhe Wang (Dahkki), Xiaotong Sun (Dahkki), Dan Wang (Dahkki), Xinbo Xu (Dahkki), Liping Yang (Dahkki), Jiangdong Du (Dahkki), Zhimei Zhou (Dahkki), Yanhua Qi (Dahkki), Linfeng Ma (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Valproic acid (VPA) has been widely used as an antiepileptic drug for decades. Although VPA is effective and well-tolerated, long-term VPA treatment is usually associated with hepatotoxicity. However, the underlying mechanisms of VPA-caused hepatotoxicity remain unclear. In this study, a total of 15...