Associations between one-carbon metabolism and valproic acid-induced liver dysfunction in epileptic patients

• Main Authors: Jingwei Zhu (Author), Zhe Wang (Author), Xiaotong Sun (Author), Dan Wang (Author), Xinbo Xu (Author), Liping Yang (Author), Jiangdong Du (Author), Zhimei Zhou (Author), Yanhua Qi (Author), Linfeng Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Valproic acid (VPA) has been widely used as an antiepileptic drug for decades. Although VPA is effective and well-tolerated, long-term VPA treatment is usually associated with hepatotoxicity. However, the underlying mechanisms of VPA-caused hepatotoxicity remain unclear. In this study, a total of 15...