Systematic investigation of the underlying mechanisms of GLP-1 receptor agonists to prevent myocardial infarction in patients with type 2 diabetes mellitus using network pharmacology

• Main Authors: Guorong Deng (Author), Jiajia Ren (Author), Ruohan Li (Author), Minjie Li (Author), Xuting Jin (Author), Jiamei Li (Author), Jueheng Liu (Author), Ya Gao (Author), Jingjing Zhang (Author), Xiaochuang Wang (Author), Gang Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Several clinical trials have demonstrated that glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) reduce the incidence of non-fatal myocardial infarction (MI) in patients with type 2 diabetes mellitus (T2DM). However, the underlying mechanism remains unclear. In this study, we...