TFAM-deficient mouse skin fibroblasts - an ex vivo model of mitochondrial dysfunction

• Päätekijät: Manuel J. Del Rey (Tekijä), Carolina Meroño (Tekijä), Cristina Municio (Tekijä), Alicia Usategui (Tekijä), María Mittelbrunn (Tekijä), Inés García-Consuegra (Tekijä), Gabriel Criado (Tekijä), José L. Pablos (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2021-08-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function. Taking advantage of Tfamfl/fl UBC-Cre/ERT2+/+ m...