TFAM-deficient mouse skin fibroblasts - an ex vivo model of mitochondrial dysfunction

• Main Authors: Manuel J. Del Rey (Author), Carolina Meroño (Author), Cristina Municio (Author), Alicia Usategui (Author), María Mittelbrunn (Author), Inés García-Consuegra (Author), Gabriel Criado (Author), José L. Pablos (Author)
• Format: Knjiga
• Izdano: The Company of Biologists, 2021-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function. Taking advantage of Tfamfl/fl UBC-Cre/ERT2+/+ m...