TFAM-deficient mouse skin fibroblasts - an ex vivo model of mitochondrial dysfunction

• Autors principals: Manuel J. Del Rey (Autor), Carolina Meroño (Autor), Cristina Municio (Autor), Alicia Usategui (Autor), María Mittelbrunn (Autor), Inés García-Consuegra (Autor), Gabriel Criado (Autor), José L. Pablos (Autor)
• Format: Llibre
• Publicat: The Company of Biologists, 2021-08-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function. Taking advantage of Tfamfl/fl UBC-Cre/ERT2+/+ m...