Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach.

• Главные авторы: Florencia Ferraro (Автор), Alicia Merlino (Автор), Nicolás Dell Oca (Автор), Jorge Gil (Автор), José F Tort (Автор), Mercedes Gonzalez (Автор), Hugo Cerecetto (Автор), Mauricio Cabrera (Автор), Ileana Corvo (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2016-07-01T00:00:00Z.
• Предметы: article
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BACKGROUND:Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...