Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach.

• Main Authors: Florencia Ferraro (Author), Alicia Merlino (Author), Nicolás Dell Oca (Author), Jorge Gil (Author), José F Tort (Author), Mercedes Gonzalez (Author), Hugo Cerecetto (Author), Mauricio Cabrera (Author), Ileana Corvo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...