Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

• 主要な著者: Ryan D. Jones (著者), Jie Liao (著者), Xin Tong (著者), Dandan Xu (著者), Leyu Sun (著者), Haonan Li (著者), Guang-Yu Yang (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function as signaling molecules. A critical PUFA, arachidonic acid (ARA), is metabolized to a diverse set of lipids signaling...