Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

• Main Authors: Ryan D. Jones (Author), Jie Liao (Author), Xin Tong (Author), Dandan Xu (Author), Leyu Sun (Author), Haonan Li (Author), Guang-Yu Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function as signaling molecules. A critical PUFA, arachidonic acid (ARA), is metabolized to a diverse set of lipids signaling...