Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study

• Hoofdauteurs: Salma Fares (Auteur), Khalid B. Selim (Auteur), Fatma E. Goda (Auteur), Magda A. A. El-Sayed (Auteur), Nawaf A. AlSaif (Auteur), Mohamed M. Hefnawy (Auteur), Alaa A.-M (Auteur), Adel S. El-Azab (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Onderwerpen: article
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New cyanobenzofurans derivatives 2-12 were synthesised, and their antiproliferative activity was examined compared to doxorubicin and Afatinib (IC50 = 4.17-8.87 and 5.5-11.2 µM, respectively). Compounds 2 and 8 exhibited broad-spectrum activity against HePG2 (IC50 = 16.08-23.67 µM), HCT-116 (IC50 =...