Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study

• Asıl Yazarlar: Salma Fares (Yazar), Khalid B. Selim (Yazar), Fatma E. Goda (Yazar), Magda A. A. El-Sayed (Yazar), Nawaf A. AlSaif (Yazar), Mohamed M. Hefnawy (Yazar), Alaa A.-M (Yazar), Adel S. El-Azab (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

New cyanobenzofurans derivatives 2-12 were synthesised, and their antiproliferative activity was examined compared to doxorubicin and Afatinib (IC50 = 4.17-8.87 and 5.5-11.2 µM, respectively). Compounds 2 and 8 exhibited broad-spectrum activity against HePG2 (IC50 = 16.08-23.67 µM), HCT-116 (IC50 =...