Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics

• Main Authors: Hani A. Alhadrami (Author), Ahmed M. Sayed (Author), Sami A. Melebari (Author), Asem A. Khogeer (Author), Wesam H. Abdulaal (Author), Mohamed B. Al-Fageeh (Author), Mohammad Algahtani (Author), Mostafa E. Rateb (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated in-silico-based approach supported by in-vitro enzyme-based and cell-based validation...