Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics

• Prif Awduron: Hani A. Alhadrami (Awdur), Ahmed M. Sayed (Awdur), Sami A. Melebari (Awdur), Asem A. Khogeer (Awdur), Wesam H. Abdulaal (Awdur), Mohamed B. Al-Fageeh (Awdur), Mohammad Algahtani (Awdur), Mostafa E. Rateb (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated in-silico-based approach supported by in-vitro enzyme-based and cell-based validation...