Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics

• Autori principali: Hani A. Alhadrami (Autore), Ahmed M. Sayed (Autore), Sami A. Melebari (Autore), Asem A. Khogeer (Autore), Wesam H. Abdulaal (Autore), Mohamed B. Al-Fageeh (Autore), Mohammad Algahtani (Autore), Mostafa E. Rateb (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated in-silico-based approach supported by in-vitro enzyme-based and cell-based validation...