Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

• Autores principales: Cecile Lebon (Autor), Heike Neubauer (Autor), Marianne Berdugo (Autor), Kimberley Delaunay (Autor), Elke Markert (Autor), Kolja Becker (Autor), Katja S. Baum-Kroker (Autor), Jürgen Prestle (Autor), Holger Fuchs (Autor), Remko A. Bakker (Autor), Francine Behar-Cohen (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-07-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Rho-associated kinase (ROCK) activation was shown to contribute to microvascular closure, retinal hypoxia, and to retinal pigment epithelium (RPE) barrier disruption in a rat model of diabetic retinopathy. Fasudil, a clinically approved ROCK inhibitor, improved retinal perfusion and reduced edema in...