Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy

• Main Authors: Rebecca Oelkrug (Author), Beate Herrmann (Author), Cathleen Geissler (Author), Lisbeth Harder (Author), Christiane Koch (Author), Hendrik Lehnert (Author), Henrik Oster (Author), Henriette Kirchner (Author), Jens Mittag (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Maternal and environmental factors control the epigenetic fetal programming of the embryo, thereby defining the susceptibility for metabolic or endocrine disorders in the offspring. Pharmacological interventions required as a consequence of gestational problems, e.g. hypertension, can pot...