CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin

• Main Authors: Jiro Tashiro (Author), Akihiro Sugiura (Author), Tomoko Warita (Author), Nanami Irie (Author), Danang Dwi Cahyadi (Author), Takuro Ishikawa (Author), Katsuhiko Warita (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Statins, which are cholesterol synthesis inhibitors, are well-known therapeutics for dyslipidemia; however, some studies have anticipated their use as anticancer agents. However, epithelial cancer cells show strong resistance to statins through an increased expression of HMG-CoA reductase (HMGCR), a...