CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin

• Asıl Yazarlar: Jiro Tashiro (Yazar), Akihiro Sugiura (Yazar), Tomoko Warita (Yazar), Nanami Irie (Yazar), Danang Dwi Cahyadi (Yazar), Takuro Ishikawa (Yazar), Katsuhiko Warita (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Statins, which are cholesterol synthesis inhibitors, are well-known therapeutics for dyslipidemia; however, some studies have anticipated their use as anticancer agents. However, epithelial cancer cells show strong resistance to statins through an increased expression of HMG-CoA reductase (HMGCR), a...