CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin

• Päätekijät: Jiro Tashiro (Tekijä), Akihiro Sugiura (Tekijä), Tomoko Warita (Tekijä), Nanami Irie (Tekijä), Danang Dwi Cahyadi (Tekijä), Takuro Ishikawa (Tekijä), Katsuhiko Warita (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Statins, which are cholesterol synthesis inhibitors, are well-known therapeutics for dyslipidemia; however, some studies have anticipated their use as anticancer agents. However, epithelial cancer cells show strong resistance to statins through an increased expression of HMG-CoA reductase (HMGCR), a...