Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.

• Main Authors: Michael Callahan (Author), Anthony M Treston (Author), Grace Lin (Author), Marla Smith (Author), Brian Kaufman (Author), Mansoora Khaliq (Author), Lisa Evans DeWald (Author), Kevin Spurgers (Author), Kelly L Warfield (Author), Preeya Lowe (Author), Matthew Duchars (Author), Aruna Sampath (Author), Urban Ramstedt (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>UV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in vivo efficacy against b...