Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.

• Autores principales: Michael Callahan (Autor), Anthony M Treston (Autor), Grace Lin (Autor), Marla Smith (Autor), Brian Kaufman (Autor), Mansoora Khaliq (Autor), Lisa Evans DeWald (Autor), Kevin Spurgers (Autor), Kelly L Warfield (Autor), Preeya Lowe (Autor), Matthew Duchars (Autor), Aruna Sampath (Autor), Urban Ramstedt (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2022-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

<h4>Background</h4>UV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in vivo efficacy against b...