Nanomedicine Against Aβ Aggregation by β-Sheet Breaker Peptide Delivery: In Vitro Evidence

• 主要な著者: Francesca Pederzoli (著者), Barbara Ruozi (著者), Jason Duskey (著者), Simone Hagmeyer (著者), Ann Katrin Sauer (著者), Stefanie Grabrucker (著者), Romina Coelho (著者), Natalia Oddone (著者), Ilaria Ottonelli (著者), Eleonora Daini (著者), Michele Zoli (著者), Maria Angela Vandelli (著者), Giovanni Tosi (著者), Andreas M. Grabrucker (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2019-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability to cross the blood−brain barrier. In this work, we<b> </b>study...