Nanomedicine Against Aβ Aggregation by β-Sheet Breaker Peptide Delivery: In Vitro Evidence

• Main Authors: Francesca Pederzoli (Author), Barbara Ruozi (Author), Jason Duskey (Author), Simone Hagmeyer (Author), Ann Katrin Sauer (Author), Stefanie Grabrucker (Author), Romina Coelho (Author), Natalia Oddone (Author), Ilaria Ottonelli (Author), Eleonora Daini (Author), Michele Zoli (Author), Maria Angela Vandelli (Author), Giovanni Tosi (Author), Andreas M. Grabrucker (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability to cross the blood−brain barrier. In this work, we<b> </b>study...