Generalizability of polygenic prediction models: how is the R2 defined on test data?

• Main Authors: Christian Staerk (Author), Hannah Klinkhammer (Author), Tobias Wistuba (Author), Carlo Maj (Author), Andreas Mayr (Author)
• Format: Knjiga
• Izdano: BMC, 2024-05-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background Polygenic risk scores (PRS) quantify an individual's genetic predisposition for different traits and are expected to play an increasingly important role in personalized medicine. A crucial challenge in clinical practice is the generalizability and transferability of PRS mode...