The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

• Hoofdauteurs: He Li (Auteur), Tianyuan Ye (Auteur), Xingyang Liu (Auteur), Rui Guo (Auteur), Xiuzhao Yang (Auteur), Yangyi Li (Auteur), Dongmei Qi (Auteur), Yihua Wei (Auteur), Yifan Zhu (Auteur), Lei Wen (Auteur), Xiaorui Cheng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Based on single-cell sequencing of the hippocampi of 5× familiar Alzheimer's disease (5× FAD) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and Alzheimer's disease (AD) mice. Blood brain barrier injury may also have contributed t...