The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

• Main Authors: He Li (Author), Tianyuan Ye (Author), Xingyang Liu (Author), Rui Guo (Author), Xiuzhao Yang (Author), Yangyi Li (Author), Dongmei Qi (Author), Yihua Wei (Author), Yifan Zhu (Author), Lei Wen (Author), Xiaorui Cheng (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on single-cell sequencing of the hippocampi of 5× familiar Alzheimer's disease (5× FAD) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and Alzheimer's disease (AD) mice. Blood brain barrier injury may also have contributed t...