The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

• Glavni autori: He Li (Autor), Tianyuan Ye (Autor), Xingyang Liu (Autor), Rui Guo (Autor), Xiuzhao Yang (Autor), Yangyi Li (Autor), Dongmei Qi (Autor), Yihua Wei (Autor), Yifan Zhu (Autor), Lei Wen (Autor), Xiaorui Cheng (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2023-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Based on single-cell sequencing of the hippocampi of 5× familiar Alzheimer's disease (5× FAD) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and Alzheimer's disease (AD) mice. Blood brain barrier injury may also have contributed t...