Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged mdx/utrn haploinsufficient (+/−) mice

• Hoofdauteurs: Sacha V. Kepreotis (Auteur), Jae Gyun Oh (Auteur), Mina Park (Auteur), Jimeen Yoo (Auteur), Cholong Lee (Auteur), Mark Mercola (Auteur), Roger J. Hajjar (Auteur), Dongtak Jeong (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2024-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Dystrophic cardiomyopathy is a significant feature of Duchenne muscular dystrophy (DMD). Increased cardiomyocyte cytosolic calcium (Ca2+) and interstitial fibrosis are major pathophysiological hallmarks that ultimately result in cardiac dysfunction. MicroRNA-25 (miR-25) has been identified as a supp...