Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged mdx/utrn haploinsufficient (+/−) mice

• Main Authors: Sacha V. Kepreotis (Author), Jae Gyun Oh (Author), Mina Park (Author), Jimeen Yoo (Author), Cholong Lee (Author), Mark Mercola (Author), Roger J. Hajjar (Author), Dongtak Jeong (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dystrophic cardiomyopathy is a significant feature of Duchenne muscular dystrophy (DMD). Increased cardiomyocyte cytosolic calcium (Ca2+) and interstitial fibrosis are major pathophysiological hallmarks that ultimately result in cardiac dysfunction. MicroRNA-25 (miR-25) has been identified as a supp...