Thioredoxin 2 protects mice against experimental myocardial infarction

• Main Authors: Tania Medali (Author), Dominique Couchie (Author), Nathalie Mougenot (Author), Maria Mihoc (Author), Olaf Bergmann (Author), Wouter Derks (Author), Celio X Santos (Author), Bertrand Friguet (Author), Mustapha Rouis (Author)
• Format: Knjiga
• Izdano: Bioscientifica, 2024-04-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Experimental Myocardial infarction (MI) using ligation procedure induces cardiac dysfunction, high level of ROS, inflammation, apoptosis, fibrosis and cardiomyocyte (CM) loss. AAV overexpressing human Trx-2, specifically in CM mitochondria improves mouse cardiac function, reduces the size of cardiac...