Thioredoxin 2 protects mice against experimental myocardial infarction

• Autores principales: Tania Medali (Autor), Dominique Couchie (Autor), Nathalie Mougenot (Autor), Maria Mihoc (Autor), Olaf Bergmann (Autor), Wouter Derks (Autor), Celio X Santos (Autor), Bertrand Friguet (Autor), Mustapha Rouis (Autor)
• Formato: Libro
• Publicado: Bioscientifica, 2024-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Experimental Myocardial infarction (MI) using ligation procedure induces cardiac dysfunction, high level of ROS, inflammation, apoptosis, fibrosis and cardiomyocyte (CM) loss. AAV overexpressing human Trx-2, specifically in CM mitochondria improves mouse cardiac function, reduces the size of cardiac...