Antidepressant-like Effects of <i>Cannabis sativa</i> L. Extract in an Lipopolysaccharide Model: Modulation of Mast Cell Activation in Deep Cervical Lymph Nodes and Dura Mater

• Egile Nagusiak: Joonyoung Shin (Egilea), Dong-Uk Kim (Egilea), Gi-Sang Bae (Egilea), Ji-Ye Han (Egilea), Do-Won Lim (Egilea), Young-Mi Lee (Egilea), Eunjae Kim (Egilea), Eunjeong Kwon (Egilea), Dongwoon Han (Egilea), Sungchul Kim (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2024-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: Lipopolysaccharide (LPS)-induced neuroinflammation is a well-established model for studying depression-like behavior, driven by pro-inflammatory cytokines such as TNF-α and IL-1β. Mast cells (MCs) contribute to neuroinflammation by releasing mediators that exacerbate depressive-like symp...