Antidepressant-like Effects of <i>Cannabis sativa</i> L. Extract in an Lipopolysaccharide Model: Modulation of Mast Cell Activation in Deep Cervical Lymph Nodes and Dura Mater

• Main Authors: Joonyoung Shin (Author), Dong-Uk Kim (Author), Gi-Sang Bae (Author), Ji-Ye Han (Author), Do-Won Lim (Author), Young-Mi Lee (Author), Eunjae Kim (Author), Eunjeong Kwon (Author), Dongwoon Han (Author), Sungchul Kim (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Lipopolysaccharide (LPS)-induced neuroinflammation is a well-established model for studying depression-like behavior, driven by pro-inflammatory cytokines such as TNF-α and IL-1β. Mast cells (MCs) contribute to neuroinflammation by releasing mediators that exacerbate depressive-like symp...