Inhibition of Peroxisome Proliferator-Activated Receptor γ Promotes Tumorigenesis Through Activation of the β-Catenin / T Cell Factor (TCF) Pathway in the Mouse Intestine

• Main Authors: Toshio Fujisawa (Author), Michiko Sugiyama (Author), Ayako Tomimoto (Author), Koichiro Wada (Author), Hiroki Endo (Author), Hirokazu Takahashi (Author), Kyoko Yoneda (Author), Masato Yoneda (Author), Masahiko Inamori (Author), Satoru Saito (Author), Yasuo Terauchi (Author), Takashi Kadowaki (Author), Naoto Tsuchiya (Author), Hitoshi Nakagama (Author), Atsushi Nakajima (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although peroxisome proliferator-activated receptor γ (PPARγ) is strongly expressed in the intestinal epithelium, the role of PPARγ in intestinal tumorigenesis has not yet been elucidated. To address this issue, we investigated the effect of PPARγ inhibition and its mechanism on intestinal tumorigen...