Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells

• المؤلفون الرئيسيون: Pedro Barrios-Bernal (مؤلف), Norma Hernandez-Pedro (مؤلف), Mario Orozco-Morales (مؤلف), Rubí Viedma-Rodríguez (مؤلف), José Lucio-Lozada (مؤلف), Federico Avila-Moreno (مؤلف), Andrés F. Cardona (مؤلف), Rafael Rosell (مؤلف), Oscar Arrieta (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The combination of metformin and TKIs for non-small cell lung cancer has been proposed as a strategy to overcome resistance of neoplastic cells induced by several molecular mechanisms. This study sought to investigate the effects of a second generation TKI afatinib, metformin, or their combination o...