Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells

• Main Authors: Pedro Barrios-Bernal (Author), Norma Hernandez-Pedro (Author), Mario Orozco-Morales (Author), Rubí Viedma-Rodríguez (Author), José Lucio-Lozada (Author), Federico Avila-Moreno (Author), Andrés F. Cardona (Author), Rafael Rosell (Author), Oscar Arrieta (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The combination of metformin and TKIs for non-small cell lung cancer has been proposed as a strategy to overcome resistance of neoplastic cells induced by several molecular mechanisms. This study sought to investigate the effects of a second generation TKI afatinib, metformin, or their combination o...