Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells

• मुख्य लेखकों: Pedro Barrios-Bernal (लेखक), Norma Hernandez-Pedro (लेखक), Mario Orozco-Morales (लेखक), Rubí Viedma-Rodríguez (लेखक), José Lucio-Lozada (लेखक), Federico Avila-Moreno (लेखक), Andrés F. Cardona (लेखक), Rafael Rosell (लेखक), Oscar Arrieta (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The combination of metformin and TKIs for non-small cell lung cancer has been proposed as a strategy to overcome resistance of neoplastic cells induced by several molecular mechanisms. This study sought to investigate the effects of a second generation TKI afatinib, metformin, or their combination o...