mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability

• Main Authors: Wilfrid Mazier (Author), Nicolas Saucisse (Author), Vincent Simon (Author), Astrid Cannich (Author), Giovanni Marsicano (Author), Federico Massa (Author), Daniela Cota (Author)
• Format: Book
• Published: Elsevier, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The hypothalamic paraventricular nucleus (PVN) is a key target of the melanocortin system, which orchestrates behavioral and metabolic responses depending on energy availability. The mechanistic target of rapamycin complex 1 (mTORC1) and the endocannabinoid type 1 receptor (CB1R) pathways...