LC-UV method to assay raloxifene hydrochloride in rat plasma and its application to a pharmacokinetic study

• Main Authors: Márcia Camponogara Fontana (Author), João Víctor Laureano (Author), Betielli Forgearini (Author), Paula dos Santos Chaves (Author), Bibiana Verlindo de Araujo (Author), Ruy Carlos Ruver Beck (Author)
• Format: Book
• Published: Universidade de São Paulo.
• Subjects: article
• Online Access: Connect to this object online.

A specific, precise, and accurate LC-UV method was developed and validated to assay raloxifene hydrochloride in rat plasma. Raloxifene was analyzed after liquid-liquid extraction and quantified by reversed phase liquid chromatography (C18 column) using acetonitrile and ammonium acetate buffer 0.05 M...